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Sale rallied briefly after the restart but a superb team try finished off by Luke Wallace and a further penalty from Botica set the Quins on the road to victory. A late converted try from replacement Jack Clifford rewarded Quins' second half dominance.
Harlequins v Sale Sharks
Quins had the better of the opening quarter but their only reward was a simple penalty from Botica and that was soon nullified when Cipriani kicked one for the visitors after 25 minutes.
Ben Botica scored an impressive 14 points as Quins moved into sixth place in the Aviva Premiership table.
Six minutes before the interval, Quins received a big blow when number eight Tom Guest was carried off on a stretcher, to be replaced by Michael Kors Hamilton East West Satchel
had a battle on their hands as Sale fiercely contested every ruck and maul but behind the scrum Quins had the edge and ultimately that paid dividends.
The replacement was hauled down but Quins recycled for Evans to put in a superbly judged crossfield kick to the waiting Luke Wallace, who had no difficulty in collecting to score.
However, the home side received Michael Kors Wallet Navy an immediate boost when Botica kicked his third penalty to give Quins a 9 3 interval lead.
when Cipriani's restart again went straight out of play.
Botica put his side back in front with his second penalty with the home side gaining further impetus Michael Kors Wallet Amazon
The first half was dour with the only scores coming from penalty kicks, three from Ben Botica to one from Danny Cipriani giving the hosts a 9 3 interval lead.
The disappointing Cipriani was replaced by Joe Ford as Sale emptied their bench in the hope of reversing their fortunes but it was to no avail as Ford's kick was charged down by Clifford, who raced away to clinch victory with a try which Botica converted.
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Quins were nowhere their best but after their recent efforts, they will be happy with their win against a determined but disappointing Sale as the visitors offered very little in attack.
The Sale wing was spoken to by the referee and was fortunate not to pick up a yellow card.
Botica's conversion rebounded back off a post but he added a further penalty after Mark Cueto was penalised for deliberately impeding Wallace, who was set to retrieve another crossfield kick.
Danny Care was brought on for Karl Dickson and immediately Quins scored a splendid try. Nick Easter broke away before an exquisite pass from Botica sent Clifford racing into the visitors 22.
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